When kratom is consumed; the opioid and stimulant-like effects are produced by the activation of opioid receptors found throughout the body. Specifically, kratom activates mu-opioid receptors as a partial agonist and kappa- and delta-opioid receptors as a competitive antagonist. It’s also thought to activate alpha-2 adrenergic and 5-HT2A receptors.

It is important to notice that albeit Best kratom for pain is understood to cause opiate-like effects, it’s not an opiate. In fact, it’s often used as an alternate to opiates because it doesn’t cause any significant breathing depression which may be a tragic side effect related to opiate use.

Kratom users who stick with an optimal dose rarely report any negative side effects. However if abuse Kratom like other supplements and medicines of its nature are often abused. When that happens users can experience symptoms which can include agitation, aggression, constipation, delusions, respiratory depression, hallucinations, hyper-pigmentation, insomnia, nervousness, and nausea, …